Sodium thiosulfate serves as a sulfur donor for the enzyme rhodanese, also known as thiosulfate sulfurtransferase. Cyanide inhibits cytochrome oxidase which prevents cells from using oxygen, resulting in low tissue oxygen ( hypoxia), high acidity (metabolic acidosis), and eventually, cellular death.

Cyanide binds to cytochrome a3, a component of the cytochrome oxidase, an enzyme essential for cellular respiration. Pedmark brand of sodium thiosulfate is used to reduce toxicity to the ear (ototoxicity) in pediatric patients, caused by the cancer chemotherapy drug cisplatin.Ĭyanide poisoning can result from inhalation, ingestion, or skin exposure to cyanide-containing compounds, including smoke from closed-space fires. Sodium thiosulfate is sequentially administered as an intravenous (IV) injection after sodium nitrite IV injection and both drugs are typically used together to reverse the effects of cyanide.

Sodium thiosulfate is a medication used as an antidote to cyanide poisoning. What is sodium thiosulfate, and what is it used for?

Sodium thiosulfate as poison antidote